Dr. Pramod K. Yadav is an Associate Professor and Ramalingaswami Fellow in the Department of Life Sciences and Biotechnology. He earned his Ph.D. in Biotechnology from D.D.U. Gorakhpur University. Following this, he briefly worked at TIFR, (2009–2010) as a Research Associate.
In 2010, Dr. Yadav moved to the University of Michigan Medical School’s Department of Biological Chemistry. During his time there (2010-2018), he expanded his expertise in enzymology and protein biochemistry, focusing on structural biology. In 2018, Dr. Yadav joined the Life Sciences Institute (LSI), University of Michigan. At LSI, he mastered single-particle cryo-electron microscopy and successfully solved the 3D structures of proteins, protein complexes, and virus-antibody complexes.
Dr. Yadav is the recipient of several prestigious national and international fellowships, including the CSIR-SRF (2008), the American Heart Association Postdoctoral Fellowship (2013), and the DBT-Ramalingaswami Re-entry Fellowship (2020). His research has been published in high-impact journals such as JBC, JACS, Cell, PNAS, and Cell Chemical Biology. Throughout his career at the University of Michigan, Dr. Yadav has managed multiple research projects and trained several undergraduate, graduate students and postdoctoral researchers.
Research Area:
- His research focuses on the molecular, cellular, and structural enzymology of enzymes and membrane proteins involved in hydrogen sulfide (H₂S) metabolism and signaling. Key enzymes studied include cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), mercaptopyruvate sulfurtransferase (MST), sulfide quinone oxidoreductase (SQR), and cysteine aminotransferase (CAT), all of which play critical roles in regulating H₂S levels and its biological functions in humans.
- Additionally, his work explores microbial enzymes with potential therapeutic applications and industrial relevance. These enzymes are of interest for their roles in bioremediation, industrial catalysis, and the development of novel therapeutic strategies.
Selected Publications:
- P K Yadav, K Yamada, T Chiku, M Koutmos, R Banerjee. JBC, 2013; 288: 20002-20013.
- M Libiad*, P K Yadav*, V Vitvitsky, M Martinov, R Banerjee. JBC, 2014; 289: 30901-30910.
*equal contributors in alphabetical order
- P K Yadav, M Martinov, V Vitvitsky, J Seravalli, R Wedmann, MR Filipovic, R Banerjee. JACS, 2016; 138: 289-299.
- P K Yadav, V Vitvitsky, H Kim, A White, U Cho and R Banerjee. JBC, 2019; 294, 11011-11022.
- L E Williamson, T Gilliland, P K Yadav, E Binshtein, R Bombardi, N Kose, R S Nargi, R M Sutton, C L Durie, E Armstrong, R H Carnahan, L M Walker, A S Kim, J Fox, M S Diamond, M D Ohi, W B Klimstra,J E Crowe. Cell, 2020; 183, 1884-1900.e23.
- P K Yadav#, S Barman, J Rajbongshi, R Mishra, S Maske, B Sudhamalla, S Mazumdar. Peptide Science, 2024; (Accepted).
Opportunities
- Candidates who have qualified NET-JRF/CSJMU PhD entrance test and wish to learn Enzymology and Protein Biochemistry and those who wish to apply for Post-Doc fellowship (i.e. CSIR, DBT, DST, ICMR, etc.), are encouraged to contact ypramod@csjmu.ac.in